Ionomycin

Modify Date: 2025-08-23 18:53:00

Ionomycin Structure
Ionomycin structure
 Common Name Ionomycin
CAS Number 56092-81-0 Molecular Weight 709.00500
Density 1.072 g/cm3 Boiling Point 817.2ºC at 760 mmHg
Molecular Formula C41H72O9 Melting Point N/A
MSDS Chinese USA Flash Point 235.2ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ionomycin


Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.

 Names

Name ionomycin
Synonym More Synonyms

 Ionomycin Biological Activity

Description Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.
Related Catalog
Target

Calcium channel[1].

In Vitro Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005[1]. It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
References

[1]. Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.

[2]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.

 Chemical & Physical Properties

Density 1.072 g/cm3
Boiling Point 817.2ºC at 760 mmHg
Molecular Formula C41H72O9
Molecular Weight 709.00500
Flash Point 235.2ºC
Exact Mass 708.51800
PSA 153.75000
LogP 7.79960
Index of Refraction 1.512
Storage condition −20°C
Water Solubility Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NO0600000
CHEMICAL NAME :
Ionomycin
CAS REGISTRY NUMBER :
56092-81-0
LAST UPDATED :
199107
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C41-H70-O9
MOLECULAR WEIGHT :
707.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,815,1978

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 36-36/37/39-27-26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NO0650000
HS Code 2941500000

 Synthetic Route

 Customs

HS Code 2941500000

 Articles66

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 Synonyms

10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadienoic acid
Ionomycin
Ionomycin free acid,(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid
Ionomycin,Free Acid,from Streptomyces conglbatus
MFCD00036890
Ionomycinefreeacid
Ionomycin from Streptomyces conglobatus
IONOMYCIN,STREPTOMYCES CONGLOBATUS
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
Ionomycin free acid
Ionomycin,Free Acid,Streptomyces conglobatus
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