Beclobrate

Modify Date: 2025-08-27 15:27:30

Beclobrate Structure
Beclobrate structure
 Common Name Beclobrate
CAS Number 55937-99-0 Molecular Weight 346.84800
Density 1.128g/cm3 Boiling Point 437.5ºC at 760mmHg
Molecular Formula C20H23ClO3 Melting Point N/A
MSDS N/A Flash Point 149.6ºC

 Use of Beclobrate


Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1].

 Names

Name Beclobrate
Synonym More Synonyms

 Beclobrate Biological Activity

Description Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1].
Related Catalog
In Vivo On the normal diet rats, Beclobrate lowers total plasma cholesterol by 22-33.4% (10-50 mg/kg); the cholesterol reduction occurred mainly in high density lipoproteins (HDL). In addition, Beclobrate administration dramatically increases the activity of the high-affinity receptors for beta-VLDL in isolated liver membranes[1].
References

[1]. C Manzoni, et al. Differential effects of beclobrate on lipid/lipoprotein distribution in normal and hypercholesterolemic rats. Eur J Pharmacol. 1990 Nov 6;190(1-2):39-49.

 Chemical & Physical Properties

Density 1.128g/cm3
Boiling Point 437.5ºC at 760mmHg
Molecular Formula C20H23ClO3
Molecular Weight 346.84800
Flash Point 149.6ºC
Exact Mass 346.13400
PSA 35.53000
LogP 5.04140
Index of Refraction 1.541
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK7761040
CHEMICAL NAME :
Butanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)-
CAS REGISTRY NUMBER :
55937-99-0
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H23-Cl-O3
MOLECULAR WEIGHT :
346.88
WISWESSER LINE NOTATION :
GR D1R DOX2&1&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,237,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4214095

 Safety Information

HS Code 2918990090

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Turec
Beclipur
Beclofibrat
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