D-Aminoglutethimide

Modify Date: 2024-01-05 16:42:47

D-Aminoglutethimide Structure
D-Aminoglutethimide structure
Common Name D-Aminoglutethimide
CAS Number 55511-44-9 Molecular Weight 232.27800
Density 1.173g/cm3 Boiling Point 457.4ºC at 760 mmHg
Molecular Formula C13H16N2O2 Melting Point 115.5-119.5ºC(lit.)
MSDS USA Flash Point 230.4ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of D-Aminoglutethimide


(R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].

 Names

Name (R)-aminoglutethimide
Synonym More Synonyms

 D-Aminoglutethimide Biological Activity

Description (R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].
Related Catalog
In Vivo (R)-(+)-Aminoglutethimide (5, 50 mg/kg; p.o.) eliminates within 48 hr into urine and feces, mostly in the form of metabolites[2]. (R)-(+)-Aminoglutethimide (1, 10, 50 mg/kg; i.p.; 60 min before training) dose not induce any significant effect in 1 and 10 mg/kg, induces a loss of retention at 50 mg/kg in day-old chicks[3].
References

[1]. Dai Sig Im, et al. Chemo-enzymatic synthesis of (R)-(+)-aminoglutethimide by kinetic resolution of (±)-4-cyano-4-phenyl-1-hexanol. Journal of Molecular Catalysis B: Enzymatic. 2003, 26:185–191.

[2]. Egger H, Bartlett F, Itterly W, Rodebaugh R, Shimanskas C. Metabolism of aminoglutethimide in the rat. Drug Metab Dispos. 1982 Jul-Aug;10(4):405-12.

 Chemical & Physical Properties

Density 1.173g/cm3
Boiling Point 457.4ºC at 760 mmHg
Melting Point 115.5-119.5ºC(lit.)
Molecular Formula C13H16N2O2
Molecular Weight 232.27800
Flash Point 230.4ºC
Exact Mass 232.12100
PSA 72.19000
LogP 1.73730
Index of Refraction 1.566

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Synthetic Route

 Synonyms

(3R)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
Aminoglutethimide,d
MFCD03094025