Myriceric acid B

Modify Date: 2025-08-26 12:19:35

Use of Myriceric acid B

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent[1][2].

Name	(3β)-27-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}-3-hydroxy olean-12-en-28-oic acid
Synonym	More Synonyms

Description	Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1:8.3±0.2 μg/mL (IC50, infection of HIV-1 Env pseudovirus)
In Vitro	Myriceric acid B (0-30 μM; 72 h) 对肿瘤细胞有强烈的细胞毒性[1]。 Myriceric acid B 抑制 HIV-1 Env 假病毒感染的 IC50 为 8.3±0.2 mg/L[2]。 Cell Cytotoxicity Assay[1] Cell Line: A549, SK-OV-3, SK-MEL-2 and Bt549 Concentration: 0-30 μM Incubation Time: 72 h Result: Exhibited potent cytotoxicity against all of the tumor cell lines tested, with IC50s of 5.7±0.3, 9.8±0.5, 6.0±0.7 and 5.8±0.4 μM against A549, SK-OV-3, SK-MEL-2 and Bt549, respectively.
References	[1]. Eom HJ, et al. Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chem Biodivers. 2017 Apr;14(4). [2]. Xia C, et al. The anti-HIV-1 entrance activity and mechanism of action of myriceric acid B from Rhoiptelea chiliantha Diels et Hand-Mazz. Chinese Pharmacological Bulletin, 2010: 447-452.

Density	1.2±0.1 g/cm3
Boiling Point	752.3±60.0 °C at 760 mmHg
Molecular Formula	C₃₉H₅₄O₇
Molecular Weight	634.842
Flash Point	227.0±26.4 °C
Exact Mass	634.386963
PSA	124.29000
LogP	9.07
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.610
InChIKey	IZCSLJUDQLFLNO-OUFIAWICSA-N
SMILES	CC1(C)CCC2(C(=O)O)CCC3(COC(=O)C=Cc4ccc(O)c(O)c4)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC43C)C2C1

Hazard Codes	Xi

(3β)-27-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}-3-hydroxyolean-12-en-28-oic acid

Myriceron caffeoyl ester

Myriceric acid B

myriceric acid A

Olean-12-en-28-oic acid, 27-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3-hydroxy-, (3β)-

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