LASV inhibitor 3.3
Modify Date: 2025-09-23 09:32:59
LASV inhibitor 3.3 structure
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Common Name | LASV inhibitor 3.3 | ||
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| CAS Number | 554438-52-7 | Molecular Weight | 471.645 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H37N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LASV inhibitor 3.3LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo virus (LUJV) or Junin virus (JUNV), Ebola virus (EBOV) or vesicular stomatitis virus (VSV); inhibits LAMP1 binding to LASV GP, which is cholesterol-dependent and sensitive to 3.3 inhibition; LASV inhibitor 3.3 is a competitive inhibitor of cholesterol binding to LAMP1. |
| Name | LASV inhibitor 3.3 |
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| Description | LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo virus (LUJV) or Junin virus (JUNV), Ebola virus (EBOV) or vesicular stomatitis virus (VSV); inhibits LAMP1 binding to LASV GP, which is cholesterol-dependent and sensitive to 3.3 inhibition; LASV inhibitor 3.3 is a competitive inhibitor of cholesterol binding to LAMP1. |
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| References | References 1. Wang MK, et al. PLoS Pathog. 2018 Sep 28;14(9):e1007322. 2. PCT Int. Appl. (2013), WO 2013022550 A2 20130214. View Related Products by Target Arenavirus |
| Molecular Formula | C30H37N3O2 |
|---|---|
| Molecular Weight | 471.645 |
| InChIKey | CUSOKWBOIRFXDP-UHFFFAOYSA-N |
| SMILES | O=C(CNC(=O)C12CC3CC(CC(C3)C1)C2)N1CCN(C(c2ccccc2)c2ccccc2)CC1 |