Rhamnazin

Modify Date: 2025-08-20 11:23:06

Rhamnazin structure	Common Name	Rhamnazin
	CAS Number	552-54-5	Molecular Weight	330.29
	Density	1.5±0.1 g/cm3	Boiling Point	591.6±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₄O₇	Melting Point	214-215℃
	MSDS	N/A	Flash Point	221.2±23.6 °C

Use of Rhamnazin

Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy[1]. Rhamnazin shows antioxidant and anti-inflammatory properties[2].

Name	3',7-Di-O-methyl Quercetin
Synonym	More Synonyms

Description	Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy[1]. Rhamnazin shows antioxidant and anti-inflammatory properties[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR2:4.68 μM (IC50)
In Vitro	Rhamnazin (5-40 μM) 抑制 VEGF 诱导的 HUVECs 增殖、迁移和成管[1]。 Rhamnazin (0-20 μM) 降低 VEGFR-2 酪氨酸激酶活性和 VEGFR-2 信号通路[1]。 Rhamnazin (0-40 μM; 24 h) 抑制乳腺癌细胞增殖和 VEGFR2 信号通路[1]。 Cell Migration Assay [1] Cell Line: HUVECs Concentration: 0, 10, 15 and 20 μM Incubation Time: 6 h Result: Strongly inhibited the migration of HUVECs. Western Blot Analysis[1] Cell Line: HUVECs Concentration: 0, 10, 15 and 20 μM Incubation Time: 24 h Result: Decreased VEGF binding to VEGFR2. Reduced VEGF-stimulated phosphorylation of VEGFR2 and its downstream MAPK, AKT, and STAT3 in HUVECs in a concentrationdependent manner. Cell Proliferation Assay[1] Cell Line: HCC1937, T-47D, SK-BR-3, MCF-7 and MDA-MB-231 Concentration: 0, 10, 15, 20, 30 and 40 μM Incubation Time: 24 h Result: Inhibited cell growth with IC50s of 19, 27, 32, 41 and 64 μM against MDA-MB-231, MCF-7, SK-BR-3, T-47D and HCC1937 in the presence of VEGF, respectively.
In Vivo	Rhamnazin (200 mg/kg; i.g.; daily for 25 days) 抑制小鼠乳腺癌生长和血管生成[1]。 Rhamnazin (5-20 mg/kg; i.p.; once) 在大鼠急性肺损伤模型中显示出较强的抗氧化和抗炎作用[2]。 Animal Model: BALB/c nude mice, breast cancer xenograft model[1] Dosage: 200 mg/kg Administration: Intragastric administration, daily for 25 days Result: Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.
References	[1]. Yu Y, et al. Rhamnazin, a novel inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy. Biochem Biophys Res Commun. 2015 Mar 20;458(4):913-9. [2]. Wu G, et al. ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS. Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):201-212.

Density	1.5±0.1 g/cm3
Boiling Point	591.6±50.0 °C at 760 mmHg
Melting Point	214-215℃
Molecular Formula	C₁₇H₁₄O₇
Molecular Weight	330.29
Flash Point	221.2±23.6 °C
Exact Mass	330.073944
PSA	109.36000
LogP	2.26
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.681

HS Code	2914509090

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Precursor 7
CAS#:64527-08-8 rhamnazin 3-O-r... CAS#:90-19-7 beta-Rhamnocitrin CAS#:854873-13-5 4-benzoyloxy-3-... CAS#:857617-58-4 2-benzoyloxy-1-...
CAS#:33554-60-8 4'-hydroxy-3,5,... CAS#:80651-75-8 hibiscatin CAS#:17874-42-9 2'-hydroxy-2,4'...
DownStream 7
CAS#:2174-64-3 flamenol CAS#:121-34-6 Vanillic acid CAS#:121-33-5 Vanillin CAS#:108-73-6 Phloroglucinol
CAS#:99-50-3 protocatechuic acid CAS#:117-39-5 Quercetin CAS#:74-88-4 methyl iodide

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one

Rhamnazin

3,4',5-Trihydroxy-3',7-dimethoxyflavone

3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one

Flavone, 3,4',5-trihydroxy-3',7-dimethoxy-

T66 BO EVJ CR DQ CO1& DQ GQ IO1

3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-chromen-4-one

3',7-Dimethylquercetin

rhamnacene

4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Rhamnazin
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.