4β-Hydroxywithanolide E

Modify Date: 2024-01-06 12:41:00

4β-Hydroxywithanolide E Structure
4β-Hydroxywithanolide E structure
 Common Name 4β-Hydroxywithanolide E
CAS Number 54334-04-2 Molecular Weight 502.59700
Density 1.39g/cm3 Boiling Point 728.3ºC at 760mmHg
Molecular Formula C28H38O8 Melting Point N/A
MSDS N/A Flash Point 242.1ºC

 Use of 4β-Hydroxywithanolide E


4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].

 Names

Name Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, .δ.-lactone

 4β-Hydroxywithanolide E Biological Activity

Description 4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].
Related Catalog
References

[1]. Momochika Kumagai, et al. 4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. J Nat Med. 2021 Jan;75(1):232-239.

 Chemical & Physical Properties

Density 1.39g/cm3
Boiling Point 728.3ºC at 760mmHg
Molecular Formula C28H38O8
Molecular Weight 502.59700
Flash Point 242.1ºC
Exact Mass 502.25700
PSA 136.82000
LogP 1.72520

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KE7283000
CHEMICAL NAME :
Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, delta-lactone, (4-beta,5-beta,6-beta,17-alpha,22R)-
CAS REGISTRY NUMBER :
54334-04-2
LAST UPDATED :
198605
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H38-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31050 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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