Vacquinol-1

Modify Date: 2024-01-05 17:51:37

Vacquinol-1 structure	Common Name	Vacquinol-1
	CAS Number	5428-80-8	Molecular Weight	352.857
	Density	1.2±0.1 g/cm3	Boiling Point	551.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	287.3±30.1 °C

Use of Vacquinol-1

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Name	[2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol
Synonym	More Synonyms

Description	Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881. [4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. [5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563.

[2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137.

[3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.

[4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1.

[5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Density	1.2±0.1 g/cm3
Boiling Point	551.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₁ClN₂O
Molecular Weight	352.857
Flash Point	287.3±30.1 °C
Exact Mass	352.134247
PSA	45.15000
LogP	3.87
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.643
Storage condition	-20℃

HS Code	2933990090

2-(4-chloro-phe...

CAS#:854864-03-2

Vacquinol-1

CAS#:5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

4-Quinolinecarb...

CAS#:7147-98-0

N/A

CAS#:198705-39-4

Vacquinol-1

CAS#:5428-80-8

Literature: Brown et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2705,2707

Precursor 2
CAS#:854864-03-2 2-(4-chloro-phe... CAS#:7147-98-0 4-Quinolinecarb...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(2-(4-chlorophenyl)-4-quinolinyl)(2-piperidinyl)methanol

4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-

[2-(4-chlorophenyl)quinolin-4-yl](piperidin-2-yl)methanol

[2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol

[2-(4-Chlor-phenyl)-[4]chinolyl]-[2]piperidyl-methanol

[2-(4-Chlorophenyl)-4-quinolinyl](2-piperidinyl)methanol

Vacquinol-1

Vacquinol-1

Use of Vacquinol-1

Names

Vacquinol-1 Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms