Zorubicin

Modify Date: 2024-01-17 18:24:46

Zorubicin structure	Common Name	Zorubicin
	CAS Number	54083-22-6	Molecular Weight	645.65600
	Density	1.54g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₅N₃O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Zorubicin

Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5].

Name	N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide
Synonym	More Synonyms

Description	Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle[2]. Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α[3]. Cell Cycle Analysis[2]. Cell Line: Human lymphoid cell line Concentration: 0.1-1 μg/mL Incubation Time: 0-24 hours Result: Time-dependently increased G2-accumulations of human lymphoid cells, delayed the traverse through G1 and the G1-S transition. Caused a stepwise accumulation of cells in G2-phase.
In Vivo	Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units[1]. Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs[3]. Animal Model: Six- to eight-week-old male DBA2 mice with P388 tumour cells[1] Dosage: 12-18 mg/kg Administration: Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection Result: Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.

Density	1.54g/cm3
Molecular Formula	C₃₄H₃₅N₃O₁₀
Molecular Weight	645.65600
Exact Mass	645.23200
PSA	210.23000
LogP	3.33700

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3345000

CHEMICAL NAME :: Benzoic acid, (1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyran osyl)oxy)-1,2,3,4,6,1 1- hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na phthacenyl)ethylidene )hydrazide, (2S-cis)-

CAS REGISTRY NUMBER :: 54083-22-6

LAST UPDATED :: 199703

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C34-H35-N3-O10

MOLECULAR WEIGHT :: 645.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22500 ug/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42500 ug/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 2150 ug/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,167,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2089 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 229 (estimated) No. of Female Employees: 82 (estimated)

Rubidazone

ZORUBICIN

Zorubicina [INN-Spanish]

zorubicine

Benzoylhydrazone daunorubicin

Zorubicin [INN]

daunomycin benzoylhydrazone

Zorubicine [INN-French]

Rubidazon

Zorubicinum [INN-Latin]

Zorubicin

Use of Zorubicin

Names

Zorubicin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Synonyms