TP3011
Modify Date: 2025-08-26 07:29:31
TP3011 structure
|
Common Name | TP3011 | ||
|---|---|---|---|---|
| CAS Number | 534605-74-8 | Molecular Weight | 474.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H26N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TP3011TP3011 is a potent topoisomerase-1 inhibitor and is the active metabolite converted from TP3076 by aldehyde oxidase 1 (AOX1)[1]. TP3011 has robust anti-tumor activities against cancer cell lines[2]. |
| Name | TP3011 |
|---|
| Description | TP3011 is a potent topoisomerase-1 inhibitor and is the active metabolite converted from TP3076 by aldehyde oxidase 1 (AOX1)[1]. TP3011 has robust anti-tumor activities against cancer cell lines[2]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | TP3011 (0-100 nM; 72 hours) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively[2]. Cell Proliferation Assay[2] Cell Line: HCT116, QG56, and NCI-H460 (NSCLC) cells Concentration: 0-100 nM Incubation Time: 72 hours Result: Was against human cancer cell lines, such as CRC and NSCLC cell lines. |
| References |
| Molecular Formula | C26H26N4O5 |
|---|---|
| Molecular Weight | 474.51 |
| InChIKey | SEFCGEILTGZHAO-SANMLTNESA-N |
| SMILES | CCCCCN1C(=O)Nc2cccc3nc4c(c1c23)Cn1c-4cc2c(c1=O)COC(=O)C2(O)CC |