Cibenzoline

Modify Date: 2024-01-02 23:04:11

Cibenzoline Structure
Cibenzoline structure
Common Name Cibenzoline
CAS Number 53267-01-9 Molecular Weight 262.34900
Density 1.17 g/cm3 Boiling Point 449.2ºC
Molecular Formula C18H18N2 Melting Point 103-104°
MSDS N/A Flash Point 225.5ºC

 Use of Cibenzoline


Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].

 Names

Name Cibenzoline
Synonym More Synonyms

 Cibenzoline Biological Activity

Description Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].
Related Catalog
Target

KATP channel[1]

References

[1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481.

[2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524.

 Chemical & Physical Properties

Density 1.17 g/cm3
Boiling Point 449.2ºC
Melting Point 103-104°
Molecular Formula C18H18N2
Molecular Weight 262.34900
Flash Point 225.5ºC
Exact Mass 262.14700
PSA 24.39000
LogP 2.75870
Index of Refraction 1.655

 Safety Information

HS Code 2933290090

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Cibenzolinum [inn-latin]
UP 33-901
Cibenzolinum
Exacor
4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole
Cibenzolina
Cibenol
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole
Ro 22-7796
[15N]-Cibenzoline
Cifenline
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Cibenzoline
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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