Cibenzoline

Names

[ Name ]:
Cibenzoline

[Synonym ]:
Cibenzolinum [inn-latin]
UP 33-901
Cibenzolinum
Exacor
4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole
Cibenzolina
Cibenol
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole
Ro 22-7796
[15N]-Cibenzoline
Cifenline

Biological Activity

[Description]:

Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

KATP channel[1]

[References]

[1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481.

[2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524.

Chemical & Physical Properties

[ Density]:
1.17 g/cm3

[ Boiling Point ]:
449.2ºC

[ Melting Point ]:
103-104°

[ Molecular Formula ]:
C₁₈H₁₈N₂

[ Molecular Weight ]:
262.34900

[ Flash Point ]:
225.5ºC

[ Exact Mass ]:
262.14700

[ PSA ]:
24.39000

[ LogP ]:
2.75870

[ Index of Refraction ]:
1.655

Safety Information

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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