(R)-Trolox
Modify Date: 2024-01-10 15:58:35
(R)-Trolox structure
|
Common Name | (R)-Trolox | ||
|---|---|---|---|---|
| CAS Number | 53101-49-8 | Molecular Weight | 250.29000 | |
| Density | 1.219g/cm3 | Boiling Point | 450.3ºC at 760 mmHg | |
| Molecular Formula | C14H18O4 | Melting Point | 162ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 171ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of (R)-Trolox(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1]. |
| Name | (2R)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | (R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent[1]. |
| References |
| Density | 1.219g/cm3 |
|---|---|
| Boiling Point | 450.3ºC at 760 mmHg |
| Melting Point | 162ºC (dec.)(lit.) |
| Molecular Formula | C14H18O4 |
| Molecular Weight | 250.29000 |
| Flash Point | 171ºC |
| Exact Mass | 250.12100 |
| PSA | 66.76000 |
| LogP | 2.48570 |
| Index of Refraction | 1.567 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2932999099 |
| Precursor 8 | |
|---|---|
| DownStream 0 | |
CAS#:70897-17-5
CAS#:56305-04-5
CAS#:77257-11-5
CAS#:103808-42-0
CAS#:77286-98-7
CAS#:123294-74-6
CAS#:123294-75-7
CAS#:123294-76-8| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Novel compounds designed as antistress agents.
J. Med. Chem. 52 , 7315-8, (2009) Agents against biologic stress were designed, containing GABA esterified with lorazepam and amidated with (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (5) or 3,5-di-tert-butyl-4-hydroxyb... |
| MFCD00180755 |
| (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| (S)-(-)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid |
| (-)-(S)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid |
| UNII-1O8B70QB9P |
| (S)-(-)-Trolox C |
| (S)-Trolox(TM) |
| (R)-TROLOX |