Simvastatin acid calcium hydrate
Modify Date: 2025-08-25 18:37:15
Simvastatin acid calcium hydrate structure
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Common Name | Simvastatin acid calcium hydrate | ||
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| CAS Number | 530112-57-3 | Molecular Weight | 965.27100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C50H84CaO15 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Simvastatin acid calcium hydrateSimvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2]. |
| Name | calcium,(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate,trihydrate |
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| Synonym | More Synonyms |
| Description | Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2]. |
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| Related Catalog | |
| Target |
HMG-CoA reductase, Reactive oxygen species[1][2] |
| In Vitro | Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2]. Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2]. Western Blot Analysis[2] Cell Line: hCM and HEK293 (transfected with OATP3A1) Concentration: 0.1, 1, 10 and 20 μM Incubation Time: 24 h Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells. |
| References |
| Molecular Formula | C50H84CaO15 |
|---|---|
| Molecular Weight | 965.27100 |
| Exact Mass | 964.54400 |
| PSA | 241.47000 |
| LogP | 5.34910 |
| UNII-QSL5L73L0O |
| Tenivastatin calcium hydrate |