530112-57-3
530112-57-3 structure
- Name: Simvastatin acid calcium hydrate
- Chemical Name: calcium,(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate,trihydrate
- CAS Number: 530112-57-3
- Molecular Formula: C50H84CaO15
- Molecular Weight: 965.27100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
- Create Date: 2017-12-12 16:29:40
- Modify Date: 2024-01-02 12:39:06
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Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
| Name | calcium,(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate,trihydrate |
|---|---|
| Synonyms |
UNII-QSL5L73L0O
Tenivastatin calcium hydrate |
| Description | Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2]. |
|---|---|
| Related Catalog | |
| Target |
HMG-CoA reductase, Reactive oxygen species[1][2] |
| In Vitro | Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2]. Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2]. Western Blot Analysis[2] Cell Line: hCM and HEK293 (transfected with OATP3A1) Concentration: 0.1, 1, 10 and 20 μM Incubation Time: 24 h Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells. |
| References |
| Molecular Formula | C50H84CaO15 |
|---|---|
| Molecular Weight | 965.27100 |
| Exact Mass | 964.54400 |
| PSA | 241.47000 |
| LogP | 5.34910 |