Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

Modify Date: 2024-01-02 18:50:56

Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)- Structure
Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)- structure
Common Name Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-
CAS Number 53-02-1 Molecular Weight 366.49200
Density 1.253g/cm3 Boiling Point 65-67ºC(lit.)
Molecular Formula C21H34O5 Melting Point -108ºC(lit.)
MSDS N/A Flash Point 297.6ºC

 Use of Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-


Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].

 Names

Name tetrahydrocortisol
Synonym More Synonyms

  Biological Activity

Description Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
Target

Human Endogenous Metabolite

References

[1]. Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408.

[2]. Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66(2):147-59.

 Chemical & Physical Properties

Density 1.253g/cm3
Boiling Point 65-67ºC(lit.)
Melting Point -108ºC(lit.)
Molecular Formula C21H34O5
Molecular Weight 366.49200
Flash Point 297.6ºC
Exact Mass 366.24100
PSA 97.99000
LogP 1.65330
Index of Refraction n20/D 1.407(lit.)
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4460000
CHEMICAL NAME :
5-beta-Pregnan-20-one, 3-alpha,11-beta,17,21-tetrahydroxy-
CAS REGISTRY NUMBER :
53-02-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H34-O5
MOLECULAR WEIGHT :
366.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Human Liver
DOSE/DURATION :
2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37
RIDADR UN 2056 3/PG 2
RTECS LU5950000

 Synonyms

5beta-Tetrahydrocortisol
Urocortisol
3alpha,5beta-Tetrahydrocortisol
Cortisol,tetrahydro
Tetrahydro F
Tetrahydrohydrocortisone
Tetrahydrocompound F
2-hydroxy-1-[(3R,5R,8S,9S,10S,11S,13S,14S,17R)-3,11,17-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
Ba 2682
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