Motilin (26-47), human, porcine
Motilin (26-47), human, porcine structure
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Common Name | Motilin (26-47), human, porcine | ||
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| CAS Number | 52906-92-0 | Molecular Weight | 2699.05000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C120H188N34O35S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Motilin (26-47), human, porcineMotilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. |
| Name | Motilin porcine |
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| Synonym | More Synonyms |
| Description | Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. |
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| Related Catalog | |
| Target |
EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1] Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)[1] |
| In Vitro | [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2]. |
| References |
| Molecular Formula | C120H188N34O35S |
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| Molecular Weight | 2699.05000 |
| Exact Mass | 2697.37000 |
| PSA | 1191.49000 |
| LogP | 4.75460 |
| InChIKey | LVRVABPNVHYXRT-UHFFFAOYSA-N |
| SMILES | CCC(C)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)Cc1ccccc1)C(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)O)C(C)O |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons.
Eur. J. Neurosci. 37(3) , 339-50, (2013) Some central nervous system neurons express receptors of gastrointestinal hormones, but their pharmacological actions are not well known. Previous anatomical and unit recording studies suggest that a ... |
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Gastrointestinal dysmotility: evidence and clinical management.
Curr. Opin. Clin. Nutr. Metab. Care 16(2) , 209-16, (2013) Gastrointestinal dysmotility and dysfunction underlie our difficulties in providing adequate nutrition by the enteral route to our critically ill patients.Recent studies have quantified gastric emptyi... |
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Effects of intrathecal opioids combined with low-dose naloxone on motilin and its receptor in a rat model of postoperative pain
Life Sci. 103(2) , 88-94, (2014) Aims To investigate the effects of intrathecal morphine and fentanyl combined with low-dose naloxone on the expression of motilin and its receptor in a rat model of postoperative pain. |
| Motilin (26-47), human, porcine |