Prunin

Modify Date: 2024-01-02 19:11:35

Prunin Structure
Prunin structure
Common Name Prunin
CAS Number 529-55-5 Molecular Weight 434.393
Density 1.6±0.1 g/cm3 Boiling Point 802.4±65.0 °C at 760 mmHg
Molecular Formula C21H22O10 Melting Point 222-224ºC
MSDS Chinese USA Flash Point 284.6±27.8 °C
Symbol GHS09
GHS09
Signal Word Warning

 Use of Prunin


Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 µM[1][2].

 Names

Name naringenin 7-O-β-D-glucoside
Synonym More Synonyms

 Prunin Biological Activity

Description Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 µM[1][2].
Related Catalog
In Vitro Prunin exhibited dose-dependent inhibitory activity against ONOO--mediated tyrosine nitration and stimulated glucose uptake by decreasing PTP1B expression level in insulin-resistant HepG2 cells. Prunin shows significant inhibitory activity against α-glucosidase, with an IC50 of 317 ± 2.12 µM[2].
References

[1]. Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11(516). pii: eaar5759.

[2]. Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40(1):37-48.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 802.4±65.0 °C at 760 mmHg
Melting Point 222-224ºC
Molecular Formula C21H22O10
Molecular Weight 434.393
Flash Point 284.6±27.8 °C
Exact Mass 434.121307
PSA 166.14000
LogP 0.82
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.691
Storage condition ?20°C

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Hazard Codes N
Risk Phrases 22
Safety Phrases 22-45
RIDADR UN 3077 9 / PGIII

 Articles7

More Articles
A rapid method for the determination of naringin, prunin, and naringenin applied to the assay of naringinase.

Anal. Biochem. 134(2) , 393-7, (1983)

A naringinase assay capable of distinguishing between the content of naringin, prunin, and naringenin present in the incubation mixture, is described. The amount of these compounds can be estimated by...

Antihyperlipidemic effect of flavonoids from Prunus davidiana.

J. Nat. Prod. 54(1) , 218-24, (1991)

Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-ca...

Crystal structure of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin.

J. Agric. Food Chem. 57(18) , 8643-51, (2009)

Seed storage proteins are accumulated during seed development and act as a reserve of nutrition for seed germination and young sprout growth. Plant seeds play an important role in human nutrition by p...

 Synonyms

5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromén-4-one
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-
4',5-DIHYDROXY-7-GLUCOSYLOXYFLAVANONE
5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-on
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside
naringenin 7-O-beta-D-glucoside
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl β-D-glucopyranoside
NARINGENIN-7-O-GLUCOSIDE
5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one
Naringenin-7-glucoside
PRUNIN
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Prunin
  • Price: ¥1250.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng


  • DC Chemicals Limited
  • China
  • Product Name: Prunin
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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Price: ¥2964/1g

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