Prunin

Modify Date: 2025-08-20 19:07:56

Prunin structure	Common Name	Prunin
	CAS Number	529-55-5	Molecular Weight	434.393
	Density	1.6±0.1 g/cm3	Boiling Point	802.4±65.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₂O₁₀	Melting Point	222-224ºC
	MSDS	Chinese USA	Flash Point	284.6±27.8 °C
	Symbol	GHS09	Signal Word	Warning

Use of Prunin

Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 µM[1][2].

Name	naringenin 7-O-β-D-glucoside
Synonym	More Synonyms

Description	Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 µM[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Infection Research Areas >> Metabolic Disease
In Vitro	Prunin exhibited dose-dependent inhibitory activity against ONOO--mediated tyrosine nitration and stimulated glucose uptake by decreasing PTP1B expression level in insulin-resistant HepG2 cells. Prunin shows significant inhibitory activity against α-glucosidase, with an IC50 of 317 ± 2.12 µM[2].
References	[1]. Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11(516). pii: eaar5759. [2]. Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40(1):37-48.

Density	1.6±0.1 g/cm3
Boiling Point	802.4±65.0 °C at 760 mmHg
Melting Point	222-224ºC
Molecular Formula	C₂₁H₂₂O₁₀
Molecular Weight	434.393
Flash Point	284.6±27.8 °C
Exact Mass	434.121307
PSA	166.14000
LogP	0.82
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.691
Storage condition	?20°C

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Hazard Codes	N
Risk Phrases	22
Safety Phrases	22-45
RIDADR	UN 3077 9 / PGIII

A rapid method for the determination of naringin, prunin, and naringenin applied to the assay of naringinase.

Anal. Biochem. 134(2) , 393-7, (1983)

A naringinase assay capable of distinguishing between the content of naringin, prunin, and naringenin present in the incubation mixture, is described. The amount of these compounds can be estimated by...

Antihyperlipidemic effect of flavonoids from Prunus davidiana.

J. Nat. Prod. 54(1) , 218-24, (1991)

Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-ca...

Crystal structure of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin.

J. Agric. Food Chem. 57(18) , 8643-51, (2009)

Seed storage proteins are accumulated during seed development and act as a reserve of nutrition for seed germination and young sprout growth. Plant seeds play an important role in human nutrition by p...

5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromén-4-one

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-

4',5-DIHYDROXY-7-GLUCOSYLOXYFLAVANONE

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-on

5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside

naringenin 7-O-beta-D-glucoside

5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl β-D-glucopyranoside

NARINGENIN-7-O-GLUCOSIDE

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one

Naringenin-7-glucoside

PRUNIN

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Prunin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Prunin
Price: ￥1250.0/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Prunin
Price: ￥1920.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Prunin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4H-1-Benzopyran-4-one,7-(b-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-,(2S)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Prunin

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