Angiotensin I/II (4-8)

Modify Date: 2025-08-25 16:36:48

Angiotensin I/II (4-8) Structure
Angiotensin I/II (4-8) structure
Common Name Angiotensin I/II (4-8)
CAS Number 52530-60-6 Molecular Weight 675.77400
Density 1.316 g/cm3 Boiling Point 1107.2ºC at 760 mmHg
Molecular Formula C35H45N7O7 Melting Point N/A
MSDS N/A Flash Point 623.4ºC

 Use of Angiotensin I/II (4-8)


Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide[1].

 Names

Name (2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
Synonym More Synonyms

 Angiotensin I/II (4-8) Biological Activity

Description Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide[1].
Related Catalog
References

[1]. P F Semple, et al. Angiotensin II and its heptapeptide (2-8), hexapeptide (3-8), and pentapeptide (4-8) metabolites in arterial and venous blood of man. Circ Res. 1976 Nov;39(5):671-8.  

 Chemical & Physical Properties

Density 1.316 g/cm3
Boiling Point 1107.2ºC at 760 mmHg
Molecular Formula C35H45N7O7
Molecular Weight 675.77400
Flash Point 623.4ºC
Exact Mass 675.33800
PSA 219.84000
LogP 2.85750
Index of Refraction 1.617
InChIKey UCHGVQMTIJAUOM-RSGBUPOYSA-N
SMILES CCC(C)C(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O

 Synonyms

De-(1-asp-2-arg-3-val)-angiotensin II
Angiotensin pentapeptide
Des-(asp(1)-arg(2)-val(3))-angiotensin II
L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine
tyrosylisoleusylhidstudylprolylphenylalanine
angiotensin II (4-8)
Angiotensin II (4-8) pentapeptide
angiotensin (4-8)
Ang(4-8)
Tyrosinyl-isoleucinyl-histidinyl-prolinyl-phenylalanine
Tyr-Ile-His-Pro-Phe
(Des-1,2,3)angiotensin II
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