Cyclic amide-linked angiotension I1 (ANGII) analogues have been synthesized by novel strategies, in an attempt to test the ring clustering and the charge relay bioactive conformation recently suggested. These analogues were synthesized by connecting side chain amino and carboxyl groups at positions 1 and 8, 2 and 8, 3 and 8, and 3 and 5, N- terminal amino and C-terminal carboxyl groups at positions 1 and 8, 2 and 8, and 4 and 8, ...
