Echinomycin
Modify Date: 2025-08-25 18:11:08
Echinomycin structure
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Common Name | Echinomycin | ||
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| CAS Number | 512-64-1 | Molecular Weight | 1101.26000 | |
| Density | 1.41 g/cm3 | Boiling Point | 1427.2ºC at 760 mmHg | |
| Molecular Formula | C51H64N12O12S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 817ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of EchinomycinEchinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. |
| Name | quinomycin a |
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| Synonym | More Synonyms |
| Description | Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. |
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| Related Catalog | |
| In Vitro | Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1]. RT-PCR[1] Cell Line: U251 cells Concentration: 0 nM, 0.625 nM, 1.25 nM, 5 nM, 10 nM Incubation Time: 16 hours Result: Significantly inhibited VEGF mRNA expression induced by hypoxia in a dose-dependent fashion. |
| In Vivo | Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway[2]. Animal Model: NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150[2] Dosage: 10 μg/kg Administration: Intravenous injection; for 40 days Result: Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs. |
| References |
| Density | 1.41 g/cm3 |
|---|---|
| Boiling Point | 1427.2ºC at 760 mmHg |
| Molecular Formula | C51H64N12O12S2 |
| Molecular Weight | 1101.26000 |
| Flash Point | 817ºC |
| Exact Mass | 1100.42000 |
| PSA | 352.40000 |
| LogP | 1.82630 |
| Index of Refraction | 1.536 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H361 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Hazard Codes | T: Toxic; |
| Risk Phrases | R46 |
| Safety Phrases | 53-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | JW5250000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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Regulatory effect of hypoxia-inducible factor-1α on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary.
J. Reprod. Dev. 58(6) , 678-84, (2012) Endothelin (ET)-2 plays a crucial role in ovarian ovulation in mammals. The present study was designed to test the hypothesis that hypoxia-inducible factor (HIF)-1α-mediated transcriptional activation... |
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Interaction of an echinomycin-DNA complex with manganese ions.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 7) , 660-4, (2009) The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This comple... |
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Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins.
Exp. Mol. Med. 44(10) , 615-21, (2012) Echinomycin is a small-molecule inhibitor of hypoxia- inducible factor-1 DNA-binding activity, which plays a crucial role in ovarian ovulation in mammalians. The present study was designed to test the... |
| echinomycin |
| quinomycin-A |