Isoprothiolane

Modify Date: 2025-08-20 10:20:43

Isoprothiolane structure	Common Name	Isoprothiolane
	CAS Number	50512-35-1	Molecular Weight	290.39900
	Density	1.228 g/cm3	Boiling Point	353ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₈O₄S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	159ºC
	Symbol	GHS07	Signal Word	Warning

Use of Isoprothiolane

Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1].

Name	isoprothiolane
Synonym	More Synonyms

Description	Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Matazaemon Uchida, et al. Effect of a Rice Blast Controlling Agent, Isoprothiolane, on Nilaparvata Lugens Stal with Different Levels of Susceptibility to Diazinon. Pest Resistance to Pesticides pp 421-428

Density	1.228 g/cm3
Boiling Point	353ºC at 760 mmHg
Molecular Formula	C₁₂H₁₈O₄S₂
Molecular Weight	290.39900
Flash Point	159ºC
Exact Mass	290.06500
PSA	103.20000
LogP	2.58120
Index of Refraction	1.546

Isoprothiolane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY1846000

CHEMICAL NAME :: Propanedioic acid, 1,3-dithiolan-2-ylidene-, bis(1-methylethyl) ester

CAS REGISTRY NUMBER :: 50512-35-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C12-H18-O4-S2

MOLECULAR WEIGHT :: 290.42

WISWESSER LINE NOTATION :: T5SYSTJ BUYVOY1&1&VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C174,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,506,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (27),20,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xi,Xn
Risk Phrases	R22:Harmful if swallowed. R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes.
Safety Phrases	S26-S39
RIDADR	UN 3077 9 / PGIII
HS Code	2934100018

tetraisopropyl ...

CAS#:147848-85-9

~62%

Isoprothiolane

CAS#:50512-35-1

Literature: Ikeda, Yukari; Ishibashi, Fumito; Shiotsuki, Takahiro; Kuwano, Eiichi; Eto, Morifusa Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 2 p. 288 - 293

diisopropyl 2-(...

CAS#:147848-87-1

~46%

Isoprothiolane

CAS#:50512-35-1

Literature: Ikeda, Yukari; Ishibashi, Fumito; Shiotsuki, Takahiro; Kuwano, Eiichi; Eto, Morifusa Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 2 p. 288 - 293

CAS#:147848-84-8

Isoprothiolane

CAS#:50512-35-1

Literature: Ikeda, Yukari; Ishibashi, Fumito; Shiotsuki, Takahiro; Kuwano, Eiichi; Eto, Morifusa Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 2 p. 288 - 293

isoprothiolane ...

CAS#:52303-69-2

Isoprothiolane

CAS#:50512-35-1

Literature: Ikeda, Yukari; Ishibashi, Fumito; Shiotsuki, Takahiro; Kuwano, Eiichi; Eto, Morifusa Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 2 p. 288 - 293

Precursor 2
CAS#:147848-85-9 tetraisopropyl ... CAS#:52303-69-2 isoprothiolane ...
DownStream 1
CAS#:52303-69-2 isoprothiolane ...

HS Code	2934100018

Sensitivity analysis using a diffuse pollution hydrologic model to assess factors affecting pesticide concentrations in river water.

Water Sci. Technol. 62(11) , 2579-89, (2010)

We quantitatively evaluated the factors that affect the concentrations of rice-farming pesticides (an herbicide and a fungicide) in river water by a sensitivity analysis using a diffuse pollution hydr...

Effects of paddy water and some photosensitizers on the photolysis of the fungicide isoprothiolane.

J. Environ. Sci. Health B 15(2) , 135-46, (1980)

The fungicide isoprothiolane (diisopropyl 1,3-dithiolan-2-ylidenemalonate) decomposed slowly in deionized water under ultraviolet light or sunlight irradiation. Rice-paddy water greatly accelerated th...

Effects of isoprothiolane and phytosterol on lipogenesis and lipolysis in adipocytes from rats of dietary fat necrosis.

Nippon. Juigaku Zasshi. 52(6) , 1189-97, (1990)

To study effects of isoprothiolane and phytosterol on dietary fat necrosis, 3 groups of rats were fed hardened-tallow (HT) diet. Two groups of rats received either isoprothiolane (50 mg/kg) or phytost...

di(propan-2-yl) (1,3-dithiolan-2-ylidene)propanedioate

MFCD00210314

bis(1-methylethyl) 2-(1,3-dithiolan-2-ylidene)propanedioate

diisopropyl 1,3-dithiolan-2-ylidenemalonate

Isoprothiolane

dipropan-2-yl 2-(1,3-dithiolan-2-ylidene)propanedioate

Diisopropyl 2-(1,3-dithiolan-2-ylidene)malonate

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Isoprothiolane

Use of Isoprothiolane

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Isoprothiolane Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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