3-Nitropropanoic acid

Modify Date: 2024-01-02 19:37:48

3-Nitropropanoic acid structure	Common Name	3-Nitropropanoic acid
	CAS Number	504-88-1	Molecular Weight	119.076
	Density	1.4±0.1 g/cm3	Boiling Point	303.0±25.0 °C at 760 mmHg
	Molecular Formula	C₃H₅NO₄	Melting Point	68-70ºC(lit.)
	MSDS	Chinese USA	Flash Point	148.4±11.6 °C
	Symbol	GHS06	Signal Word	Danger

Use of 3-Nitropropanoic acid

3-Nitropropanoic acid is an irreversible inhibitor of succinate dehydrogenase.

Name	3-nitropropanoic acid
Synonym	More Synonyms

Description	3-Nitropropanoic acid is an irreversible inhibitor of succinate dehydrogenase.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	succinate dehydrogenase[1]
References	[1]. Huang LS, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72.

Density	1.4±0.1 g/cm3
Boiling Point	303.0±25.0 °C at 760 mmHg
Melting Point	68-70ºC(lit.)
Molecular Formula	C₃H₅NO₄
Molecular Weight	119.076
Flash Point	148.4±11.6 °C
Exact Mass	119.021858
PSA	83.12000
LogP	-0.08
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.463
Stability	Stable. Incompatible with strong oxidizing agents, bases, reducing agents.
Water Solubility	alcohol: 100 mg/mL, may be light yellow

3-Nitropropanoic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF6220000

CHEMICAL NAME :: Propionic acid, 3-nitro-

CAS REGISTRY NUMBER :: 504-88-1

BEILSTEIN REFERENCE NO. :: 1759889

LAST UPDATED :: 199706

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H5-N-O4

MOLECULAR WEIGHT :: 119.09

WISWESSER LINE NOTATION :: WN2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68100 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1870 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	25-36/37/38
Safety Phrases	26-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	UF6220000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2915900090

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Precursor 6
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DownStream 7
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HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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BioBioPha
China
Product Name: 3-Nitropropanoic acid
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propanoic acid,3-nitro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 3-NITROPROPIONIC ACID
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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3-Nitropropanoic acid

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