PHA-408

Modify Date: 2024-01-21 15:30:37

PHA-408 structure	Common Name	PHA-408
	CAS Number	503555-55-3	Molecular Weight	560.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₇ClFN₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PHA-408

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].

Name	8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide
Synonym	More Synonyms

Description	PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IKK-2
References	[1]. Rajendrasozhan S, et al. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81.