PHA-408

Names

[ Name ]:
PHA-408

[Synonym ]:
pha-408

Biological Activity

[Description]:

PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Inflammation/Immunology

[Target]

IKK-2

[References]

[1]. Rajendrasozhan S, et al. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₇ClFN₇O₂

[ Molecular Weight ]:
560.02

[ Exact Mass ]:
559.19000

[ PSA ]:
113.86000

[ LogP ]:
5.19950

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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