N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine

Modify Date: 2025-08-26 12:25:43

N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine Structure
N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine structure
Common Name N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine
CAS Number 501081-38-5 Molecular Weight 458.642
Density 1.2±0.1 g/cm3 Boiling Point 659.9±55.0 °C at 760 mmHg
Molecular Formula C28H38N6 Melting Point N/A
MSDS N/A Flash Point 352.9±31.5 °C

 Use of N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine


FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM; inhibits the interaction of TSG101 with its cognate viral ligands; displays an ability to prevent lethality from Ebola in vivo; well-tolerated and orally bioavailable.

 Names

Name FGI-106
Synonym More Synonyms

  Biological Activity

Description FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM; inhibits the interaction of TSG101 with its cognate viral ligands; displays an ability to prevent lethality from Ebola in vivo; well-tolerated and orally bioavailable.
References References 1. Kinch MS, et al. Am J Transl Res. 2009 Jan 5;1(1):87-98. 2. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77. View Related Products by Target Filovirus

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 659.9±55.0 °C at 760 mmHg
Molecular Formula C28H38N6
Molecular Weight 458.642
Flash Point 352.9±31.5 °C
Exact Mass 458.315796
LogP 5.17
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.678
InChIKey WJUPENLNVUCETH-UHFFFAOYSA-N
SMILES Cc1cc(NCCCN(C)C)c2ccc3c(ccc4c(NCCCN(C)C)cc(C)nc43)c2n1

 Synonyms

FGI-106
BRT994456W
N,N'-Bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
Quino[8,7-h]quinoline-1,7-diamine, N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethyl-
FGI-106 FREE BASE
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