501081-38-5
501081-38-5 structure
- Name: N,N'-bis-(3-dimethylamino-propyl)-3,9-dimethylquinolino[8,7-h]quinolin-1,7-diamine
- Chemical Name: FGI-106
- CAS Number: 501081-38-5
- Molecular Formula: C28H38N6
- Molecular Weight: 458.642
- Catalog: Signaling Pathways Anti-infection HCV
- Create Date: 2020-01-11 18:53:31
- Modify Date: 2025-08-26 12:25:43
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FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM; inhibits the interaction of TSG101 with its cognate viral ligands; displays an ability to prevent lethality from Ebola in vivo; well-tolerated and orally bioavailable.
| Name | FGI-106 |
|---|---|
| Synonyms |
FGI-106
BRT994456W N,N'-Bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine Quino[8,7-h]quinoline-1,7-diamine, N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethyl- FGI-106 FREE BASE |
| Description | FGI-106 is a broad-spectrum inhibitor of multiple blood-borne viruses (HCV, HBV, HIV) as well as emerging biothreats (Ebola, VEE, Cowpox, PRRSV infection) with EC50 of 0.2-10 uM; inhibits the interaction of TSG101 with its cognate viral ligands; displays an ability to prevent lethality from Ebola in vivo; well-tolerated and orally bioavailable. |
|---|---|
| References | References 1. Kinch MS, et al. Am J Transl Res. 2009 Jan 5;1(1):87-98. 2. De Clercq E. Med Res Rev. 2013 Nov;33(6):1249-77. View Related Products by Target Filovirus |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 659.9±55.0 °C at 760 mmHg |
| Molecular Formula | C28H38N6 |
| Molecular Weight | 458.642 |
| Flash Point | 352.9±31.5 °C |
| Exact Mass | 458.315796 |
| LogP | 5.17 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.678 |