Demethoxydeacetoxypseudolaric acid B analog

Modify Date: 2025-08-26 19:11:43

Demethoxydeacetoxypseudolaric acid B analog Structure
Demethoxydeacetoxypseudolaric acid B analog structure
Common Name Demethoxydeacetoxypseudolaric acid B analog
CAS Number 500736-17-4 Molecular Weight 376.400
Density 1.4±0.1 g/cm3 Boiling Point 665.9±55.0 °C at 760 mmHg
Molecular Formula C24H30O8 Melting Point N/A
MSDS N/A Flash Point 238.2±25.0 °C

 Use of Demethoxydeacetoxypseudolaric acid B analog


Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM[1].

 Names

Name (1R,7S,8R,9R)-9-[(1E,3E)-4-Carboxy-1,3-pentadien-1-yl]-7-hydroxy-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylic acid
Synonym More Synonyms

  Biological Activity

Description Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM[1].
Related Catalog
References

[1]. Yang SP, et al. Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicineand a structure-activity relationship study. J Med Chem. 2008 Jan 10;51(1):77-85.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 665.9±55.0 °C at 760 mmHg
Molecular Formula C24H30O8
Molecular Weight 376.400
Flash Point 238.2±25.0 °C
Exact Mass 376.152191
LogP 1.41
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.613

 Safety Information

Hazard Codes Xi

 Synonyms

1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-4a-hydroxy-3-methyl-1-oxo-, (3R,4R,4aS,9aR)-
(1R,7S,8R,9R)-9-[(1E,3E)-4-Carboxy-1,3-pentadien-1-yl]-7-hydroxy-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-ene-4-carboxylic acid
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