tioxolone
Modify Date: 2024-01-11 21:34:31
tioxolone structure
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Common Name | tioxolone | ||
|---|---|---|---|---|
| CAS Number | 4991-65-5 | Molecular Weight | 168.170 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 377.8±44.0 °C at 760 mmHg | |
| Molecular Formula | C7H4O3S | Melting Point | 158-160 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 182.3±28.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of tioxoloneTioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.Target: Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia. |
| Name | tioxolone |
|---|---|
| Synonym | More Synonyms |
| Description | Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.Target: Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 377.8±44.0 °C at 760 mmHg |
| Melting Point | 158-160 °C(lit.) |
| Molecular Formula | C7H4O3S |
| Molecular Weight | 168.170 |
| Flash Point | 182.3±28.4 °C |
| Exact Mass | 167.988113 |
| PSA | 78.68000 |
| LogP | 1.77 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.718 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DM2953750 |
| HS Code | 2930909090 |
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tioxolone CAS#:4991-65-5 |
| Literature: Urushibara; Koga Bulletin of the Chemical Society of Japan, 1956 , vol. 29, p. 419 Full Text Show Details Pantlitschko; Benger Monatshefte fuer Chemie, 1950 , vol. 81, p. 293,299 |
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Detail
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| Literature: Urushibara; Koga Bulletin of the Chemical Society of Japan, 1956 , vol. 29, p. 419 Full Text Show Details Pantlitschko; Benger Monatshefte fuer Chemie, 1950 , vol. 81, p. 293,299 |
CAS#:103-50-4
CAS#:2553-70-0
CAS#:14665-49-7| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone).
Acta Crystallogr. C 60(Pt 6) , o395-6, (2004) The planar molecules of 6-hydroxy-1,3-benzoxathiol-2-one, C(7)H(4)O(3)S, are linked by extensive O-H.O and C-H.O hydrogen bonding and are further stablilized by face-to-face pi-pi interactions. |
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[Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one (01 1)].
Arzneimittelforschung 19(8) , 1298-304, (1969)
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Contact dermatitis from thioxolone.
Contact Dermatitis 29(2) , 96, (1993)
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| 1,3-Benzoxathiol-2-one, 6-hydroxy- |
| 6-Hydroxy-2-oxo-1,3-benzoxathiole |
| Camyna |
| Stepin |
| MFCD00005859 |
| Acnosan |
| 6-Hydroxybenzo[d][1,3]oxathiol-2-one |
| EINECS 225-653-0 |
| tioxolone |
| 6-Hydroxy-1,3-benzoxathiol-2-one |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: tioxolone
- Price: ￥918.0/25g ￥2688.0/100g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
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Price: ￥845/25g
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