Alloxazine;Isoalloxazine

Modify Date: 2024-01-06 01:23:06

Alloxazine;Isoalloxazine structure	Common Name	Alloxazine;Isoalloxazine
	CAS Number	490-59-5	Molecular Weight	214.18000
	Density	1.509g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Alloxazine;Isoalloxazine

Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].

Name	alloxazine
Synonym	More Synonyms

Description	Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	IC50: 2.9 μM (AMP)[1]
In Vitro	Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1]. Cell Viability Assay[1] Cell Line: PGT-β cells Concentration: 0-30 μM Incubation Time: 20 min Result: Inhibited the cyclic AMP generation concentration-dependently with an IC IC50 of 2.9 μM.
In Vivo	Alloxazine (1 µmol/L, 0-20 min) suppresses NECA-induced vasodilation[2]. Animal Model: 250–320 g male Sprague-Dawley rats[2] Dosage: 1 µmol/L Administration: Cortical surface suffusion; 1 µmol/L once Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.
References	[1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44.

Density	1.509g/cm3
Molecular Formula	C₁₀H₆N₄O₂
Molecular Weight	214.18000
Exact Mass	214.04900
PSA	91.50000
LogP	0.15960
Index of Refraction	1.699
Storage condition	-20℃

Alloxazine;Isoalloxazine MSDS(Chinese)

WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Alloxazin

1H-benzo[g]pteridine-2,4-dione

Alloxazine

DC Chemicals Limited
China
Product Name: Alloxazine;Isoalloxazine
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzo[g]pteridine-2,4(1H,3H)-dione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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