Alloxazine;Isoalloxazine

Names

[ CAS No. ]:
490-59-5

[ Name ]:
Alloxazine;Isoalloxazine

[Synonym ]:
Alloxazin
1H-benzo[g]pteridine-2,4-dione
Alloxazine

Biological Activity

[Description]:

Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

IC50: 2.9 μM (AMP)[1]

[In Vitro]

Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1]. Cell Viability Assay[1] Cell Line: PGT-β cells Concentration: 0-30 μM Incubation Time: 20 min Result: Inhibited the cyclic AMP generation concentration-dependently with an IC IC50 of 2.9 μM.

[In Vivo]

Alloxazine (1 µmol/L, 0-20 min) suppresses NECA-induced vasodilation[2]. Animal Model: 250–320 g male Sprague-Dawley rats[2] Dosage: 1 µmol/L Administration: Cortical surface suffusion; 1 µmol/L once Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.

[References]

[1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14.

[2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44.

Chemical & Physical Properties

[ Density]:
1.509g/cm3

[ Molecular Formula ]:
C₁₀H₆N₄O₂

[ Molecular Weight ]:
214.18000

[ Exact Mass ]:
214.04900

[ PSA ]:
91.50000

[ LogP ]:
0.15960

[ Index of Refraction ]:
1.699

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%