PMX464
Modify Date: 2025-08-25 18:26:39
PMX464 structure
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Common Name | PMX464 | ||
|---|---|---|---|---|
| CAS Number | 485842-97-5 | Molecular Weight | 243.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H9NO2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PMX464PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1]. |
| Name | 4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C13H9NO2S |
|---|---|
| Molecular Weight | 243.28 |
| Exact Mass | 243.03500 |
| PSA | 78.43000 |
| LogP | 2.17900 |
| InChIKey | SDYBYKXWYDVVKP-UHFFFAOYSA-N |
| SMILES | O=C1C=CC(O)(c2nc3ccccc3s2)C=C1 |
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~53%
PMX464 CAS#:485842-97-5 |
| Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541 |
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~%
PMX464 CAS#:485842-97-5 |
| Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541 |
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~%
PMX464 CAS#:485842-97-5 |
| Literature: Chakraborty, Mrinal; Jin, Kyoung Joo; Glover, Stephen A.; Novak, Michael Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5296 - 5304 |
![Benzo[d]thiazole structure](https://image.chemsrc.com/caspic/318/95-16-9.png)
![1-(benzo[d]thiazol-2-yl)-4-iminocyclohexa-2,5-dien-1-ol structure](https://image.chemsrc.com/caspic/361/1192371-77-9.png)
| Precursor 2 | |
|---|---|
| DownStream 1 | |
CAS#:934-34-9| UNII-YJX11V636Q |
| PMX-464 |
| AW-464 |
| Threo-methylphenidate hydrochloride |