PMX464

Names

[ Name ]:
PMX464

[Synonym ]:
UNII-YJX11V636Q
PMX-464
AW-464
Threo-methylphenidate hydrochloride

Biological Activity

[Description]:

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Callister ME, et, al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol. 2008 Nov;155(5):661-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₉NO₂S

[ Molecular Weight ]:
243.28

[ Exact Mass ]:
243.03500

[ PSA ]:
78.43000

[ LogP ]:
2.17900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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