Toddalolactone

Modify Date: 2024-01-02 10:10:31

Toddalolactone structure	Common Name	Toddalolactone
	CAS Number	483-90-9	Molecular Weight	308.326
	Density	1.3±0.1 g/cm3	Boiling Point	530.0±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₀O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	195.5±23.6 °C

Use of Toddalolactone

Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].

Name	6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
Synonym	More Synonyms

Description	Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Research Areas >> Cardiovascular Disease
In Vitro	Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].
References	[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.

Density	1.3±0.1 g/cm3
Boiling Point	530.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₀O₆
Molecular Weight	308.326
Flash Point	195.5±23.6 °C
Exact Mass	308.125977
PSA	89.13000
LogP	0.88
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.569
Storage condition	2-8C

2H-1-Benzopyr...

CAS#:137764-14-8

~15%

Toddanone

CAS#:77636-08-9

Toddalolactone

CAS#:483-90-9

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1681 - 1684

Precursor 1
CAS#:137764-14-8 2H-1-Benzopyr...
DownStream 0

2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-

6-[(2r)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2h-chromen-2-one

6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-chromen-2-one

(+)-toddalolactone

Toddaline

Toddalolactone

BioBioPha
China
Product Name: Toddalolactone
Price: ￥Inquiry/20mg
Purity: 98.0%
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Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Toddalolactone
Price: ￥1178.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
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DC Chemicals Limited
China
Product Name: toddalolactone
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: toddalolactone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: toddalolactone
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Toddalolactone

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