JF-5
Modify Date: 2025-09-18 12:46:12
JF-5 structure
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Common Name | JF-5 | ||
|---|---|---|---|---|
| CAS Number | 481687-01-8 | Molecular Weight | 290.831 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H22N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JF-5JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor; inhibits PAR1 coupling to Gα subunits, but fails to inhibit signaling downstream of Gα12/13; also interacts with the α2A-adrenergic receptor; blocks granule secretion from platelets activated with the PAR1 agonist SFLLRN with IC50 of 4 uM, inhibits AYPGKF-mediated activation of murine platelets with IC50 of 10 uM; inhibited thrombus formation in vivo following vascular injury with IC50 of 1 mg/kg; a useful probe to evaluate the role of H8 in coupling of GPCRs to cognate Gα subunits. |
| Name | MFCD23380199 |
|---|---|
| Synonym | More Synonyms |
| Description | JF5 (PAR1 inhibitor JF5) is an allosteric inhibitor of PAR1 that binds to helix 8 of the receptor; inhibits PAR1 coupling to Gα subunits, but fails to inhibit signaling downstream of Gα12/13; also interacts with the α2A-adrenergic receptor; blocks granule secretion from platelets activated with the PAR1 agonist SFLLRN with IC50 of 4 uM, inhibits AYPGKF-mediated activation of murine platelets with IC50 of 10 uM; inhibited thrombus formation in vivo following vascular injury with IC50 of 1 mg/kg; a useful probe to evaluate the role of H8 in coupling of GPCRs to cognate Gα subunits. |
|---|---|
| References | References 1. Dowal L, et al. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2951-6. View Related Products by Target Protease-activated Receptor (PAR) |
| Molecular Formula | C17H22N2 |
|---|---|
| Molecular Weight | 290.831 |
| Exact Mass | 290.154968 |
| InChIKey | NUUYLSYEZFKFHN-UHFFFAOYSA-N |
| SMILES | CCCCCn1c2c(c(=N)c3ccccc31)CCC2 |
| 4-Pentyl-1,2,3,4-tetrahydro-9H-cyclopenta[b]quinolin-9-imine hydrochloride (1:1) |
| MFCD23380199 |
| 1,2,3,4-Tetrahydro-4-pentyl-9H-cyclopenta[b]quinolin-9-imine hydrochloride |
| JF5 hydrochloride |
| 9H-Cyclopenta[b]quinolin-9-imine, 1,2,3,4-tetrahydro-4-pentyl-, hydrochloride (1:1) |