Integerrimine

Modify Date: 2024-01-09 11:53:08

Integerrimine structure	Common Name	Integerrimine
	CAS Number	480-79-5	Molecular Weight	335.39500
	Density	1.25g/cm3	Boiling Point	563.7ºC at 760 mmHg
	Molecular Formula	C₁₈H₂₅NO₅	Melting Point	172 °C
	MSDS	N/A	Flash Point	294.7ºC

Use of Integerrimine

(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].

Name	Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
Synonym	More Synonyms

Description	(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	(-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1].
References	[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

Density	1.25g/cm3
Boiling Point	563.7ºC at 760 mmHg
Melting Point	172 °C
Molecular Formula	C₁₈H₂₅NO₅
Molecular Weight	335.39500
Flash Point	294.7ºC
Exact Mass	335.17300
PSA	76.07000
LogP	1.13070
Vapour Pressure	4.68E-15mmHg at 25°C
Index of Refraction	1.57

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM9080000

CHEMICAL NAME :: Integerrimine

CAS REGISTRY NUMBER :: 480-79-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 18750 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

Hazard Codes	Xi
RIDADR	UN 1544
Packaging Group	III
Hazard Class	6.1(b)

Intergerrimine

senecionyne

Squalidine

INTEGERRIMINE

seneciionine

12-hydroxy-senecionane-11,16-dione

DC Chemicals Limited
China
Product Name: Integerrimine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: INTEGERRIMINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Integerrimine

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CHEMICAL IDENTIFICATION

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