Liriodenine

Modify Date: 2024-01-04 11:34:05

Liriodenine structure	Common Name	Liriodenine
	CAS Number	475-75-2	Molecular Weight	275.258
	Density	1.5±0.1 g/cm3	Boiling Point	531.0±19.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₉NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	275.0±21.5 °C

Use of Liriodenine

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].

Name	liriodenine
Synonym	More Synonyms

Description	Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.
References	[1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol

Density	1.5±0.1 g/cm3
Boiling Point	531.0±19.0 °C at 760 mmHg
Molecular Formula	C₁₇H₉NO₃
Molecular Weight	275.258
Flash Point	275.0±21.5 °C
Exact Mass	275.058258
PSA	48.42000
LogP	3.30
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.768

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB6036000

CHEMICAL NAME :: Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-(methylenedioxy)-

CAS REGISTRY NUMBER :: 475-75-2

BEILSTEIN REFERENCE NO. :: 0273167

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H9-NO3

MOLECULAR WEIGHT :: 975.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987

Hazard Codes	Xi

Precursor 7
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