Neriifolin

Modify Date: 2025-08-25 18:38:23

Neriifolin structure	Common Name	Neriifolin
	CAS Number	466-07-9	Molecular Weight	534.68100
	Density	1.274g/cm3	Boiling Point	700.079ºC at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₈	Melting Point	218-225ºC
	MSDS	N/A	Flash Point	224.862ºC

Use of Neriifolin

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

Name	neriifolin
Synonym	More Synonyms

Description	Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1].
References	[1]. Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237. [2]. Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.

Density	1.274g/cm3
Boiling Point	700.079ºC at 760 mmHg
Melting Point	218-225ºC
Molecular Formula	C₃₀H₄₆O₈
Molecular Weight	534.68100
Flash Point	224.862ºC
Exact Mass	534.31900
PSA	114.68000
LogP	3.11020
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.581
InChIKey	VPUNMTHWNSJUOG-BAOINKAISA-N
SMILES	COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C1O

Neriifolin MSDS(Chinese)

Hazard Codes	T+
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	FH4906100

NERIIFOLIN

17Beta-Neriifolin

xy)-14-hydroxy

digitoxigenin+thevetose

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Neriifolin
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Neriifolin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Card-20(22)-enolide,3-[(6-deoxy-3-O-methyl-a-L-glucopyranosyl)oxy]-14-hydroxy-, (3b,5b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Neriifolin

Use of Neriifolin

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Neriifolin Biological Activity

Chemical & Physical Properties

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.