Asiatic acid

Modify Date: 2025-08-21 11:11:41

Asiatic acid Structure
Asiatic acid structure
 Common Name Asiatic acid
CAS Number 464-92-6 Molecular Weight 488.699
Density 1.2±0.1 g/cm3 Boiling Point 609.4±55.0 °C at 760 mmHg
Molecular Formula C30H48O5 Melting Point 325-330 °C(lit.)
MSDS Chinese USA Flash Point 336.4±28.0 °C

 Use of Asiatic acid


Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid can be used to treat skin cancer[1]. Asiatic acid also has anti-inflammatory activities[2].

 Names

Name asiatic acid
Synonym More Synonyms

 Asiatic acid Biological Activity

Description Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid can be used to treat skin cancer[1]. Asiatic acid also has anti-inflammatory activities[2].
Related Catalog
References

[1]. Park BC, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90.

[2]. Huang SS, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 609.4±55.0 °C at 760 mmHg
Melting Point 325-330 °C(lit.)
Molecular Formula C30H48O5
Molecular Weight 488.699
Flash Point 336.4±28.0 °C
Exact Mass 488.350189
PSA 97.99000
LogP 6.46
Vapour Pressure 0.0±4.0 mmHg at 25°C
Index of Refraction 1.579
InChIKey JXSVIVRDWWRQRT-UYDOISQJSA-N
SMILES CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC43C)C2C1C
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918199090

 Synthetic Route

Asiaticoside structure

Asiaticoside

CAS#:16830-15-2

~%

Asiatic acid Structure

Asiatic acid

CAS#:464-92-6

Literature: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (SIPI) Patent: WO2009/89365 A2, 2009 ; Location in patent: Page/Page column 6-7 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles34

More Articles
Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method.

J. Ethnopharmacol. 163 , 31-8, (2015)

Asiatic acid is one of the main components in the herb Centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. To enhance the development potentials of asia...

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.

Int. Immunopharmacol. 24(2) , 232-8, (2015)

In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vi...

Effecting skin renewal: a multifaceted approach.

J. Cosmet. Dermatol. 10(2) , 126-30, (2011)

The skin undergoes intrinsic aging as a normal course, but exposure to ultraviolet (UV) light results in major cumulative damage that manifests as the typical aged photodamaged skin. UV irradiation pr...

 Synonyms

2,3,23-TRIHYDROXY-12-URSEN-28-OIC ACID
(2α,3β)-2,3,23-Trihydroxyurs-12-en-28-oic acid
Asiatic acid
Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2α,3β)-
Asiantic acid
Asiaticacid
UNII-9PA5A687X5
MFCD00238541
Dammarolic acid
EINECS 482-720-9
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