(+)-Ophiobolin A

Modify Date: 2024-01-05 19:23:42

(+)-Ophiobolin A structure	Common Name	(+)-Ophiobolin A
	CAS Number	4611-05-6	Molecular Weight	400.551
	Density	1.1±0.1 g/cm3	Boiling Point	539.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₃₆O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	177.8±23.6 °C
	Symbol	GHS06	Signal Word	Danger

Use of (+)-Ophiobolin A

Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity[1].

Name	ophiobolin A
Synonym	More Synonyms

Description	Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Infection
Target	IC50: 9 μM (calmodulin-activated cyclic nucleotide phosphodiesterase)[1].
References	[1]. Leung PC, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem. 1984 Mar 10;259(5):2742-7

Density	1.1±0.1 g/cm3
Boiling Point	539.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₆O₄
Molecular Weight	400.551
Flash Point	177.8±23.6 °C
Exact Mass	400.261353
PSA	63.60000
LogP	3.75
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.554

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RL1576000

CHEMICAL NAME :: Ophiobola-7,19-dien-25-al, 14,18-epoxy-3-hydroxy-5-oxo-, (18R)-

CAS REGISTRY NUMBER :: 4611-05-6

LAST UPDATED :: 198211

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C25-H36-O4

MOLECULAR WEIGHT :: 400.61

WISWESSER LINE NOTATION :: L C585 FV LX HUTJ A1 DQ D1 HVH L-& BT5OXTJ C1 E1UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 238 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,143,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H312 + H332
Precautionary Statements	Missing Phrase - N15.00950417-P261-P280
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	S36
RIDADR	UN 2811 6.1/PG 3
RTECS	RL1576000

COCHLIOBOLIN A

(18R)-3-Hydroxy-5-oxo-14,18-epoxyophiobola-7,19-diene-25-al

18-epoxy-3-hydroxy-5-oxo-19-dien-25-a(18r)-ophiobola-14

Ophiobolin A

cochliobolin

ophiobolin

Ophiobolin,Helminthosporium sp.

orphiobolin A

(7E,18R)-3-Hydroxy-5-oxo-14,18-epoxyophiobola-7,19-dien-25-al

Spiro[dicyclopenta[a,d]cyclooctene-3(2H),2'(3'H)-furan]-6-carboxaldehyde, 1,3a,4,4',5',6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3',9,10a-trimethyl-5'-(2-methyl-1-propen-1-yl)-7-oxo-, (3S,3'S,3aR,5E,5'R,6aS,9R,9aS,10aR)-

(18R)-14,18-Epoxy-3-hydroxy-5-oxoophiobola-7,19-dien-25-al

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: COCHLIOBOLIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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(+)-Ophiobolin A

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(+)-Ophiobolin A Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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