ML192
Modify Date: 2023-01-16 19:02:54
ML192 structure
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Common Name | ML192 | ||
|---|---|---|---|---|
| CAS Number | 460331-61-7 | Molecular Weight | 382.479 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H22N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML192ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1]. |
| Name | ML-192 |
|---|---|
| Synonym | More Synonyms |
| Description | ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1]. |
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| Related Catalog | |
| Target |
ERK2 ERK1 PKCβII |
| In Vitro | ML192 抑制 10 μM L-α 溶血磷脂酰肌醇 (LPI) 或 1 μM ML186 诱导的 β-arrestin 转运，IC50 值分别为0.70μM、0.29 µM[1]。 ML192 显著抑制表达 GPRSS 的 U2OS 细胞中 ERK1/2 的磷酸化[1]。 ML192 (0, 10, 30 和 100 µM) 减弱了野生型 GPR55 受体细胞中的 PKCβII 易位[1]。 |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H22N4O2S |
| Molecular Weight | 382.479 |
| Exact Mass | 382.146332 |
| LogP | 3.07 |
| Index of Refraction | 1.664 |
| Storage condition | 2-8°C |
| 2-furanyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone |
| Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone |
| ML-192 |
| 2-Furyl[4-(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone |
| Methanone, 2-furanyl[4-(5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]- |