SB-681323

Modify Date: 2025-08-26 18:48:21

SB-681323 Structure
SB-681323 structure
Common Name SB-681323
CAS Number 444606-18-2 Molecular Weight 456.41700
Density N/A Boiling Point N/A
Molecular Formula C23H19F3N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SB-681323


Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

 Names

Name 8-(2,6-difluorophenyl)-2-(1,3-dihydroxypropan-2-ylamino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7-one
Synonym More Synonyms

 SB-681323 Biological Activity

Description Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
Related Catalog
In Vitro Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].
References

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.

 Chemical & Physical Properties

Molecular Formula C23H19F3N4O3
Molecular Weight 456.41700
Exact Mass 456.14100
PSA 103.50000
LogP 2.36040

 Synonyms

Dilmapimod
UNII-Q3238VQW0N
SB-681323
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