<Suppliers Price>

SB-681323

Names

[ CAS No. ]:
444606-18-2

[ Name ]:
SB-681323

[Synonym ]:
Dilmapimod
UNII-Q3238VQW0N
SB-681323

Biological Activity

[Description]:

Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[In Vitro]

Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].

[References]

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.


[Related Small Molecules]

SB203580 | SB202190 (FHPI) | Doramapimod (BIRB 796) | LY2228820 | SB 239063 | Losmapimod | PD 169316 | Talmapimod | Tat-NR2B9c | Dehydrocorydaline chloride | TAK-715 | VX 702 | VX-745 | SKF 86002 | Acumapimod

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19F3N4O3

[ Molecular Weight ]:
456.41700

[ Exact Mass ]:
456.14100

[ PSA ]:
103.50000

[ LogP ]:
2.36040

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.