MMRi64
Modify Date: 2023-07-08 11:17:26
MMRi64 structure
|
Common Name | MMRi64 | ||
|---|---|---|---|---|
| CAS Number | 430458-66-5 | Molecular Weight | 410.298 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H17Cl2N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MMRi64MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a. |
| Name | MMRi64 |
|---|
| Description | MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a. |
|---|---|
| References | References 1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035. View Related Products by Target MDM2-p53 |
| Molecular Formula | C22H17Cl2N3O |
|---|---|
| Molecular Weight | 410.298 |