430458-66-5
430458-66-5 structure
- Name: MMRi64
- Chemical Name: MMRi64
- CAS Number: 430458-66-5
- Molecular Formula: C22H17Cl2N3O
- Molecular Weight: 410.298
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-12 12:51:49
- Modify Date: 2023-07-08 11:17:26
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MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.
| Name | MMRi64 |
|---|
| Description | MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a. |
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| References | References 1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035. View Related Products by Target MDM2-p53 |
| Molecular Formula | C22H17Cl2N3O |
|---|---|
| Molecular Weight | 410.298 |