LY518674

Modify Date: 2024-01-19 12:33:02

LY518674 structure	Common Name	LY518674
	CAS Number	425671-29-0	Molecular Weight	409.47800
	Density	1.21g/cm3	Boiling Point	575.852ºC at 760 mmHg
	Molecular Formula	C₂₃H₂₇N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	302.065ºC

Use of LY518674

LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].

Name	2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid
Synonym	More Synonyms

Description	LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
Target	EC50: 42 nM (human PPARα)[1]
In Vivo	LY518674 reduces triglycerides and increased HDL-C in vivo[2]. LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3].
References	[1]. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [2]. Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [3]. Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2.

Density	1.21g/cm3
Boiling Point	575.852ºC at 760 mmHg
Molecular Formula	C₂₃H₂₇N₃O₄
Molecular Weight	409.47800
Flash Point	302.065ºC
Exact Mass	409.20000
PSA	97.21000
LogP	3.34540
Index of Refraction	1.594
Storage condition	2-8°C

Precursor 5
CAS#:425672-62-4 tert-butyl 2-[4... CAS#:20637-08-5 Methyl 4-(4-met... CAS#:22320-10-1 4-Hydroxybenzen... CAS#:425672-61-3 4-[4-(1-tert-bu...
CAS#:425669-64-3 2-(4-{3-[4-(2,4...
DownStream 0

2-Methyl-2-[4-[3-[1-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid

Propanoic acid,2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl

2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid

2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl-propanoic acid

DC Chemicals Limited
China
Product Name: LY518674
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LY-518674
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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