N-aryl benzimidazole

Modify Date: 2025-08-25 14:28:14

N-aryl benzimidazole Structure
N-aryl benzimidazole structure
Common Name N-aryl benzimidazole
CAS Number 422554-26-5 Molecular Weight 375.851
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H18ClN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-aryl benzimidazole


N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells.

 Names

Name N-(2-Chlorobenzyl)-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
Synonym More Synonyms

 N-aryl benzimidazole Biological Activity

Description N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells.
References References 1. Tardiff DF, et al. Science. 2013 Nov 22;342(6161):979-83. View Related Products by Target Other Targets

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C22H18ClN3O
Molecular Weight 375.851
Exact Mass 375.113831
LogP 5.41
Index of Refraction 1.652
InChIKey MQCHTHJRANYSEJ-UHFFFAOYSA-N
SMILES Cc1cccc(-n2cnc3cc(C(=O)NCc4ccccc4Cl)ccc32)c1

 Synonyms

1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(3-methylphenyl)-
N-(2-Chlorobenzyl)-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide
MFCD15095628
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