SW155246

Modify Date: 2025-08-23 11:13:53

SW155246 Structure
SW155246 structure
 Common Name SW155246
CAS Number 420092-79-1 Molecular Weight 378.787
Density 1.6±0.1 g/cm3 Boiling Point 613.2±65.0 °C at 760 mmHg
Molecular Formula C16H11ClN2O5S Melting Point N/A
MSDS Chinese Flash Point 324.6±34.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of SW155246


SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].

 Names

Name 4-Chloro-N-(4-hydroxy-1-naphthyl)-3-nitrobenzenesulfonamide
Synonym More Synonyms

 SW155246 Biological Activity

Description SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].
Related Catalog
References

[1]. Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288(27):19673-84.

[2]. José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15(2):3253-61.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 613.2±65.0 °C at 760 mmHg
Molecular Formula C16H11ClN2O5S
Molecular Weight 378.787
Flash Point 324.6±34.3 °C
Exact Mass 378.007721
LogP 3.94
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.731
InChIKey JDYDEJYIVZNWQU-UHFFFAOYSA-N
SMILES O=[N+]([O-])c1cc(S(=O)(=O)Nc2ccc(O)c3ccccc23)ccc1Cl

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport

 Synonyms

4-Chloro-N-(4-hydroxy-1-naphthyl)-3-nitrobenzenesulfonamide
Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-
MFCD01165393
SW155246
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Chemsrc provides SW155246(CAS#:420092-79-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SW155246 are included as well.>> amp version: SW155246

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