Tromantadine hydrochloride

Modify Date: 2024-01-05 10:02:41

Tromantadine hydrochloride Structure
Tromantadine hydrochloride structure
Common Name Tromantadine hydrochloride
CAS Number 41544-24-5 Molecular Weight 316.86700
Density N/A Boiling Point 434.5ºC at 760 mmHg
Molecular Formula C16H29ClN2O2 Melting Point N/A
MSDS N/A Flash Point 216.6ºC

 Use of Tromantadine hydrochloride


Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].

 Names

Name N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide,hydrochloride
Synonym More Synonyms

 Tromantadine hydrochloride Biological Activity

Description Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].
Related Catalog
Target

HSV-1

HSV-2

In Vitro Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection[1].
References

[1]. Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.

 Chemical & Physical Properties

Boiling Point 434.5ºC at 760 mmHg
Molecular Formula C16H29ClN2O2
Molecular Weight 316.86700
Flash Point 216.6ºC
Exact Mass 316.19200
PSA 45.06000
LogP 3.29190

 Synonyms

Tromantadin hydrochlorid
Viruserol
UNII-H09LUS437B
Virumerz
Tromantadine HCl