GS-389

Modify Date: 2025-08-25 15:59:42

GS-389 Structure
GS-389 structure
Common Name GS-389
CAS Number 41498-37-7 Molecular Weight 313.39100
Density 1.108g/cm3 Boiling Point 454ºC at 760 mmHg
Molecular Formula C19H23NO3 Melting Point N/A
MSDS N/A Flash Point 191.6ºC

 Use of GS-389


GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

 Names

Name 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
Synonym More Synonyms

 GS-389 Biological Activity

Description GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].
Related Catalog
References

[1]. Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334.  

 Chemical & Physical Properties

Density 1.108g/cm3
Boiling Point 454ºC at 760 mmHg
Molecular Formula C19H23NO3
Molecular Weight 313.39100
Flash Point 191.6ºC
Exact Mass 313.16800
PSA 39.72000
LogP 3.47070
Index of Refraction 1.557
InChIKey GXTUEUWFEKEQHJ-UHFFFAOYSA-N
SMILES COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1

 Safety Information

HS Code 2933499090

 Synthetic Route

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

coclaurine dimethyl ether
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline
7,12-O,O'-dimethylcoclaurine
N-(3,4-dimethoxyphenylethyl)-2-(3-methoxyphenyl)acetamide
6,7-dimethoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline
rac-O,O-dimethylcoclaurine
GS-389
(+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
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